Retinal toxicity after repeated intravitreal carboplatin injection into rabbit eyes
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چکیده
منابع مشابه
Long-term retinal toxicity of intravitreal commercially available preserved triamcinolone acetonide (Kenalog) in rabbit eyes.
PURPOSE To investigate whether intravitreal Kenalog (IVTK; Bristol Meyers Squibb Company, Princeton, NJ) produces histologic or electroretinographic changes in the rabbit retina up to 3 months after injection. METHODS Ten Dutch-belted rabbits were injected with 4 mg/0.1 mL Kenalog in one eye and 0.1 mL physiologic salt solution (PSS) in the fellow eye. Simultaneous bilateral dark-adapted elec...
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PURPOSE To evaluate retinal toxicity of varying doses of rapamycin when injected intravitreally in rabbits. Rapamycin is a potent immunosuppressive agent with significant antitumor and antiangiogenic properties, clinically approved for prevention of organ transplant rejection. METHODS Twelve New Zealand albino rabbits were divided into four groups. Four different doses of rapamycin were prepa...
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PURPOSE To evaluate bevacizumab toxicity in neurosensorial retina and retinal pigment epithelium in pigmented rabbit eyes by means of histological studies. METHODS Thirty eyes of fifteen rabbits were distributed into three groups: sham group (S), that received a 0.1 ml balanced saline solution (BSS) intravitreal injection (10 eyes); group 1, that received a 1.25 mg (0.1 ml) bevacizumab intrav...
متن کاملRetinal pigment epithelium tear after intravitreal aflibercept injection
To report a case complicated with a retinal pigment epithelium (RPE) tear after intravitreal aflibercept injection. A 78-year-old man had deteriorated visual acuity in his left eye. Fluorescein angiography showed occult choroidal neovascularization. Optical coherence tomography showed a serous retinal detachment and fibrovascular pigment epithelial detachment. He was diagnosed as typical age-re...
متن کاملOcular biodistribution of bevasiranib following a single intravitreal injection to rabbit eyes
PURPOSE The primary objective of these investigations was to determine the ocular biodistribution of bevasiranib, a small interfering RNA (siRNA) targeting vascular endothelial growth factor A (VEGF-A), following a single intravitreal injection to rabbit eyes. METHODS A tissue distribution and pharmacokinetic study was conducted with (3)H-bevasiranib prepared in balanced-salt solution (BSS). ...
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ژورنال
عنوان ژورنال: Biomedical Papers
سال: 2014
ISSN: 1213-8118,1804-7521
DOI: 10.5507/bp.2012.106